Issue 10, 2012

The structures of type I polyketide synthases

Abstract

Covering: up to 2012

With the recent structural characterization of each of the component enzymes of type I polyketide synthases, scientists are coming tantalizingly close to elucidating the overall architectures and mechanisms of these enormous molecular factories. This review highlights not only what has been revealed about the structures and activities of each of the domains but also the mysteries that remain to be solved.

Graphical abstract: The structures of type I polyketide synthases

Article information

Article type
Review Article
Submitted
09 Feb 2012
First published
03 Aug 2012

Nat. Prod. Rep., 2012,29, 1050-1073

The structures of type I polyketide synthases

A. T. Keatinge-Clay, Nat. Prod. Rep., 2012, 29, 1050 DOI: 10.1039/C2NP20019H

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